If you reload, go with FMJ bullets to save pelts. If you dont reload, use the facortly ammo that shoots the most accurately from your gun. With the HP or varmint bullets, i suggest you make your shots, long shots and let that bullet slow down a little. I stopped using 22-250 years ago for coyotes because factory ammo blew gaping holes in them. Its not a good caliber for saving fur.