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A coyotes top speed is about 35 mph.I'd watch some videos or look to hire a guide to avoid years worth of mistakes that you'd have to learn not to do on your own. As far as lead......its usually more than you think. Most guys shoot over coyotes and shoot behind them (while running).
#2 How fast do they run top speed?
have you tryed stopping them? get some of randy andersons videos he is a legend in the coyote calling world. He uses a long deeper howl to stop them alot of the times but it depends why they are running, if they saw you then you can stop them most of the time but if they smelled you then probably not going to get it to stop atleast within range. ive shot at a few running coyotes and never hit one that i can think of right now.
the first couple coyotes i called in i was so excited i didnt even think to try and stop them i just shot.