Low odds shot, how about a double lung shot?
With ICEMAN here, seen too many starving to death deer with jaws blown off - miserable sight to behold
deers brainpan isn't very large, 45 isn't going to penetrate the nasal cavity then continue on through to the neck or spine area so you got a doe with it's nose shattered and it dies a slow painful death.
If you can shoot an egg at 30 yards over and over without missing then I take my words back