I would say any change would be minimal. I mean I guess it could change the width a little bit. Does your buck made the record books and you are worried about disqualification?
The bones do soften up a little, but not much and it all dries up pretty tight. When its all degresed properly there is a small amount of play in the antlers where the separate plates in the skull meet, but its really minimal especially after it dries for a few days or more. Usually you will degrease the skull for longer and at warmer water temp than the maceration process.