I've contemplated doing what you are talking about for high buck. After talking with a game bio he suggested I try a couple other areas that have higher animal populations since the areas around the lake have seen population declines in recent years. With that said I will probably give this hunt a try in the future because it looks like a great adventure. I was also told there are quite a few bear around the lake so I'd be prepared for taking a bear if the chance arose.
My loose plan would be to launch at 25-mile creek campground (or farther up the lake if I can find a launch), run up the lake and tie up at one of several docks along the lake and hike my way into the wilderness for a week or so. I haven't pinpointed which dock to use, but there are 15-20 federal camp areas along the lake...some have docks, some don't. I was in this area last weekend at 25-mile creek and can confirm it is a long steep hike from the lake to the top of the first ridge. I did see several creeks/waterfalls flowing into the lake so I don't think water would be a problem. Weather/water wise it was flat calm 3 out or 4 days, but blew up on the 4th day. I could have run my 16' boat in the water but it would have made for a bumpy ride. I would be reluctant to run something smaller however. I think the safest thing to do would be to build some time into your schedule for weather delays in case you have to wait an extra day going in or coming out.