I have been hunting muzzle for 8 years now and had nothing but problems for the 1st 3 years....so bad that I switched guns each of the 1st 4 years before I was recommended the T/C Thunderhawks by ".54 Thunderhawk" above in this thread.
I guess at the end of the day there are probably a few good solutions out there, and a lot of it depends on the way you hunt. For the most part if you hunt in Western WA you better be ready to battle the elements as we do every year and we have had more than our fair share of misfires from wet powder and even wet caps over the years.
I can tell you that myself and our camp of 9 have had a wide variety of guns and all but one of us have switched to T/C over the past 8 years. A couple Hawkens, 4 Thunderhawks and 2 Black Diamonds.