For me the .375 is a no brainer. It is more than capable of taking any game in the world including cape buffalo. It is way more versatile, easier to shoot(still a banger), and cheaper then the bigger guns of Africa. It is perfect for grizzly, moose, bison, polar bear, or anything else North America will present. I found it particularly comforting hunting moose with my .375 in Montana grizzly country many years ago.I knew if a bear problem occurred my gun would be enough to handle the problem. Would you really ever have a need to use the bigger African calibers for anything other than the WOW factor? Since a .375 H&H is big enough to take everything in the world why would you need something bigger. If money is no object buy anything you want. For a guy like me that money matters anything else doesn't make sense.
