From a ballistics stand point, the .52 out performs the .50. Knights recommended load is 150gr loose 777, with a 375 red hot sabot. It kicks like a mule. I started out with a .52 and bought a .50 barrel. I used the .50 for deer and the .52 for elk. I sold it to a buddy, wish I kept it. I used to get ammo through Knight, that was the only draw back.