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Either should work. You could always try both to see if your rifle has a preference.
I have a Knight Bighorn .50 and have gleaned through all the Knight manuals. I have found nothing related to this. One would think an issue as major as excessive pressures would warrant more detailed manufacturer info. SCARY!!!Here is a description of FFFG as taken from Hodgdon's website."The same great powder as FFG with smaller grain size and it is intended for use in pistols and rifles of 50 caliber and smaller."Does the Dixie Gunworks catalog have more info related to grain size?Yes, in the the POWDER section; also, for a GREAT Owner's Manual with good info., get one from Thompson Center. It has good general info. for all muzzleloaders.
The finer the grain, the faster the burn.Either one will work with a fifty.If you go for large powder loads felt recoil will be more with finer powders.Measure by volume not weight.Start out around 60 or 70 grains of powder and then increase slowly,develop a load that works.When accuracy starts to fall off,cut your load back around 10 grains or so.You don't need to shoot humungous 100+ grain loads. Remember a 45-70 shot a 400 grain bullet pushed by 70 grains of powder. YMMV