Ballisticstudies.com has a nice write up on your 25-08.States that it beats the 257 roberts and the 243,260. Use 4350 powder with nosler 115 gr on deer sized game out to 500 yrd. Coyotes wont like the 75 grainers either.Tip for brass is use 243 or 260 as neck thickness can be a problem if necking down 308's.Hope this helps.