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check compression
Does it have a timing belt? My 1990 3.0 slipped a belt and ran like crap, but no codes available.
Is it consistently cylinder #6 and no others? If so then leak down test that cylinder, inspect for coolant contamination or other issues only on that cylinder. If it is random cylinders then based on what you have done with no change then possible a fuel issue, too little or too much fuel pressure?