The best antelope caliber is....

[C-Money]

I wouldn't change anything. I would shoot the 100gr Hornaday interlock over the same dose of IMR 4350 that I used for deer.

[bearpaw]

I was just thinking today about going antelope hunting. I figured I’d go with the 338/408 improved pistol or maybe the 375 BME. I hate being under gunned. 

you are on the right track! use as big of caliber as you can handle.  Shoot them first through the hind quarters then once directly through the  both shoulders. its less that you will have to eat later.

Please don’t tell Yorke to bring as big a caliber as he can handle. Good lord there won’t be anything left of the pronghorn.

   very true 

[jasnt]

Another vote for 243. I like the Berger flavors my self