Do to a "sudden wolf migration" in 2009-2010 we along with several other folks were having problems with wolves around our homes, killing chickens, killing livestock, attacking dogs etc., so I met up with one of WDFW LEO's I asked him how close a wolf had to get before I should shoot it, he said if the wolf looked like it was interested in me, that a hundred yards would be a good distance to start at.
I talk to another LEO who said, if you have to shoot a wolf, lay down in front of it and put one in the chest.
As we saw with the lady treed by wolves a while back, WDFW will protect their wolves above all else.