I have two CZ Varmint model 17 Hornets. They're a really fun little gun and both of mine shoot very well. They're probably the quietest centerfire I've ever shot yet they still are fairly potent. I shoot mine suppressed so they're really quiet but even without a can screwed on the end they're not all that loud. I know they'll kill coyotes, not much won't, they'd just never be my first choice. They work great on ground squirrels, prairie dogs, and rock chucks.
As for reloading for the 17 Hornady Hornet, they aren't anymore or less difficult to reload for than any other CF but they do have certain quirks about them. I prefer to use a Redding bushing neck size only die. The neck thickness on the brass has a pretty big variance in it from lot to lot so I prefer using a bushing die to keep the neck tension all the same.
Also, the CZ are fed through a single stack magazine and the feeding can sometimes be a bit temperamental but there are little tricks to getting them to feed reliably so don't let it be a deal breaker.
