I started with Hornady 180 gr SST and Varget. Those might work okay on deer although I read a couple accounts that the bullet came apart and didn't penetrate. Switched to 180gr Interbond, basically exact same round, but will mushroom a little and pretty much stay as a solid slug. I like the heavier rounds, they have slower muzzle velocity, but past about 200 yards they retain more velocity than those really light super fast rounds which will be going a lot slower at that distance. They also deal with wind a bit better, so your wind estimates don't have to be as accurate. Too many people just look at that high muzzle velocity.