I was recently trying to decide the best "all around" caliber for a hunting rifle. Since I already have a Magnum and a 30-06, I chose a 270 Winchester. But the reality is there are 12-20 great options with only minimal differences in real world results. In my opinion the focus should probably be on what features are most desired in a rifle. In my case I wasn't considering home defense, so a bolt gun made the most sense for me. If that had been a consideration, I may have considered a semi auto or lever action.
For myself weight, barrel length, all weather protection, detachable magazine and a standard readily available cartridge were all on the wish list. A threaded barrel to allow a brake ( really not needed) and possibly a suppressor were a plus as well. Once you narrow down the operating system and features, the cartridge choices will likely be 2-4 standout choices as well.
