Honestly a solidly loaded 45 colt will be excellent and not as earsplitting as a .454, .357mag, or .44mag IMO.
However I think my favorite is the .480 Ruger.
Buffalo bore is my favorite ammunition maker by far and they have a great middle ground .45 colt load, 325 grains at like 1,000 fps roughly if I remember. Would do the trick for anything. And they have hotter loads for the .45 colt that are equal or better than a .44 mag.
Behind a stout .45 colt I’d say the above cartridges all are excellent.
357 mag : It’s an excellent round that has proven itself capable of defense against all but the most extreme animals. With a Buffalo bore or Grizzly load I wouldn’t feel undergunned unless I was In Africa. And then only maybe.
.44 mag: The Legendary cartridge that has taken every species of game animal on earth. More recoil than the .357 but not crazy. A good load and your set period.
.454 Casull: *censored*ING BOOM and it’s dead. Significant recoil. Be warned.
.480 Ruger: hear me out, it’s more recoil than a 44 mag but less than. .454. It is an excellent hunting and wildlife defense cartridge. The large bullet diameter doesn’t negotiate with Terrorists, or anything else. IMO it’s an excellent and reasonably shootable round.
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