I’d steer clear of the .44 for home defense. It might just be me & my skinny wrists, but managing the recoil of that takes a few seconds. At best I could manage a couple seconds in an emergency, and seconds are precious in a fight.
In my opinion sight radius doesn’t matter because you aren’t aiming at paper on the range. You’re instinctively shooting at a man size target within the confines of the walls of your house. You need to be able to put rounds where you’re looking. Choose whichever gun you do that best with.