If you can put a shot - with ANY weapon - right at the vertex of the "V" made by the scapula and the humerus (assuming broadside or slightly quartered away) your projectile will go over the top of the heart, transecting the pulmonary artery AND the aorta. This is the most immediately fatal injury which can be produced in a vertebrate short of decapitation.
Can’t they still move though? Or does this drop them in their tracks? I’m sure not too far with total system failure like that.
With a Muzzleloader at 60 yards and a kitchen counter as a rest with bags I’m probably shooting it where the base of the skull meets the neck.
With a ML bullet I have seen both shoulder shot and neck shot elk do some getting around. Not too mention hitting one in the shoulder is going to impact how much meat makes it to your freezer.
In my experience it will knock them down but they sometimes get back up.
Can you use a .300 blackout with suppressor, optic and subsonic ammo?