If a booger charges you and is on top of you in thick brush, I think any round .380 and upwards is better than fighting with your hands. That's if you can stay cool and index the weapon where it counts. Just face it, you'll probably get tore up a little, but if your alive, that's what matters.
I know that after my run-in with the pissed off sow in the brush, I'll never leave home without my .357 again. She would have been on me so fast and all I would have been able to do is feed the pistol to her while pulling the trigger.