I have and use both. Love both. If I had to chose, I could live without the 22-250. I shoot 80 grain for everything in my 243 a, soft point, not a varmit bullet. 22-250 is flat and a good killer, 243 just as flat and a better killer, about the same noise but the 243 kicks a tiny bit more.
I also use a 223, I will never feel under gunned for yotes with a 22-250. 243 doubles as a small deer gun.
Here in washington a 243 is nice in the fall cause you might call a bear, cougar or coyote, depending on where and time of year, you could take any of the 3 with a 243, of course you would need a perfect shot on a bear.
my 2.
Carl