I hope 5200 fps was a typo

, my 22-250 ackley comes nowhere near that speed. I shoot both, 22-250, 223 in an AR, a 243, and a 2506. Today, where I knew the distance was out there, I packed the 2506. But to tell the truth, I wouldn't have felt that handicapped with my AR in 223 as well. Between the 2 cartridges you mentioned, I would stick with the 223 if coyote hunting was less than 50% of it's main purpose. If it's a yote gun, and fur isn't a concern, get a 243 or 2506, or what I'm eyeing now, a 22/250 ackley, with 1/7" twist...... Or a 6.5x284win....