yep good point bearpaw about tryin to break one of the shoulder but always go for vitals first and try to break the opposite shoulder. i have shot the barnes but i had very poor results on paper with them and the only bullet i have ever shot that i have seen key hole and they were doing it at 100 yards as well not sure what was up i only use there handgun bullets now and muzzle bullets
A lot of times you may have to step down a weight when switching to a Barnes TSX or similar. They are less dense than lead, which means they are slightly longer...which can affect stabilization depending on your rifle and twist rate. This isn't necessarily a bad thing, though, because the performance of said bullet will allow you to step down to a slightly lighter bullet and still get superior performance...and a flatter trajectory.
Also, if you load your own ammunition, try to give them a .040-.060 jump off the lands. They seem to be a bit finicky until you find the right OAL for your rifle...when you get it right, you'll surely know it.