Having owned a Ruger Blackhawk in the wonderful 45lc cartridge, and having shot plus p plus ammo in it I can tell you that the problem isnt muzzle rize, bullets long gone before that. It impacts higher due to muzzle velocity, simple fix with the addition of a taller front sight post. Gary Reeder, Bowen Classic arms are two folks that work a lot on Ruger framed revolvers. The other thing you can do is to compensate for the extra height by aiming a little lower. If your shooting behind the shoulder of a deer or elk, aim mid height,center mass and tight behind the shoulder, if your 4" high you still put it in the boiler room, if your dead on at fifty your still in the boiler room and if your four low at 75, again your still in the boiler room.