Here's an opinion from another thread:
"Lots of factory ammo available for both. I'd rather shoot the .45 colt due to felt recoil. The .44 Magnum has a bit of punch. .44 Magnum ammo is a little easier to find, and a little cheaper. I love the .44 Magnum. Great all around cartridge for self defense, hunting, target practice, etc. You can also shoot the .44 Special load for target out of the .44 Mag."
I personally think both rounds are great. .44 Mag may have the edge if you are headed north or are in Moose country (which are becoming more common in many places in Washington State).
