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What kinda rifle and caliber? I'm no gun expert but I do know you subtract yardage on up and down hill shots.
Id check the cosine and account for it..But realistically unless it was a crazy angle I could just shoot it for a straight up 300 and be fine
If you were zerod at 300, you would hold low shooting up or down..
I zero my rifles at 250. There is only 3 inches drop to 300. I would hold midway up the body.