Do it all hunting rifle.

[Special T]

MJ I don't think changing bullets will change drop. HOWEVER your grouping my get better or worse depending on the gun. I would agree with the above and say that if your going to change stuff up then you should see how it groups. 

[Hunting7mm]

I shoot 7mm rem. mag model 700 with a leupold vx3 4.5x14 with the bdc.  Low profile leupold quick release scope mounts and a bsquare bipod. I shoot 160gr. accubonds and it does the job. 

[Bean Counter]

I say it depends how far out you plan on shooting, If you look at the Remington balistic calculator and compare he long range dropp of a 125 grain bullet and a 180 grain at 300 yrds its 1.4 in, 400yrds there is only 2.5" diff and @500 a 4.5in diff
So out to 300 yards there is really not any significant difference.  I have my 06 sited in with 165 grain so its a split the difference if i go up or down... But i usually shoot military ball at coyotes so i don't really care. 

Thanks for the reply. What about changing bullets? Say, going from an Accubond to a Core lokt, for example. I know guns like certain bullets better than others, but would a 165gr Remington be zeroed in for a 165gr Winchester?

Yes. So says a top authority on the topic: Maj. John Plaster, author of the widely acclaimed masterpiece "The Ultimate Sniper." When changing bullets, even in the same.grain weight, recheck your zero.