I will say that I'm sure to the OP that was with a scoped 209 gun.
Here is a whitetail buck I took this year in Ohio W/ my "scoped 209 CVA Optima" during the modern season. (Shotgun,MLer's and straight walled pistol only)
Shot this buck at 254 yards and used the 250g TEZ. 1 shot drop
shot 2 does as well. 1@ 182 yards and 1@ 145 yards...both of these the bullet passed through....

here is the spend slug 247.34g


So yea it can be done!
I myself without a scope wouldn't take more then a 100-125 yard shot with my Wa. gun(T/C BlackDiamond XR) and like the ML Reg's here in Wa.
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1149 fps & 733 ft lbs +/- at 300 yards with a 250g bullet and a MV of 1996fps
this is the bullet I used in quick load:
.452, 250, Hornady FTX 45201=BC.210