At the range I wouls start sighting in at the 50yrd and move up from there. Personally I wouldn't shoot my smoke poll out past a 150yrd. I would rather kill the game humanly than wound it. I have read were some claim they can shoot there muzzy's 200yrds open sights. I have never seen it just read about it.
Thats just my take on it, and I am sure some will agree and some will disagree. It's what I am confortable with when shooting my muzzy.