My preference is to fish below the bridge at the pipe hole/punchbowl area. Every boater is different, some will only fish certain areas, I know of guys that will only fish the pipe hole area, others that will go above and only fish the hatchery hole and so on. When the fish are really in there, the king hole should be alright. If I fish the king hole I fish the upper part of it in 25-35 foot of water early in the morning then move out to deeper water in the afternoon. The hatchery hole is up above the king hole/ power line hole and can be productive for some. We tried to fish it this year on our annual trip for every morning and didn't do good, other boats did. Then there's the lava hole above that too but I've never fished it but I know people do well there too. I haven't fished it this late for a couple years, we try to plan our trip the 2nd week of September so we don't have to wait an hour to launch the boat haha. If you're fishing that 50 foot of water and you're using multiple rods, I would put two of them more towards the bottom and if you have other rods put them at different depths or off a diver instead of a weight. If you head up to the hatchery hole, I recommend doing it during the daylight the first few times so you know where to go. There's a sandbar up where it turns right on the river and if you aren't paying attention you can get shallow pretty quick. If you go downriver to the pipehole you don't have to worry about depths. You could also run to white bluffs and launch there too and fish that hole.
