If I kept running into 300 pound deer, I might choose the 180 grain Hornady out of the 30-06 as my primary cartridge. Since I don't seem to find any, those sharp sticks I throw at them seems to work amazingly well. Basically as addicted stated "it might drop, run, or stand there" it's amazing how different each and every animal is.
Don't mind me D-man, I haven't slept in two days and its starting to show.