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Tularemic hares and cottontails have been observed to behave oddly, to run slowly, and to be captured easily. Infected rabbits appear to be tame or in a stupor; they do not raise their heads or carry their front feet well; they rub their noses and forefeet into the ground. They have recurrent muscle spasms, and stagger for a few yards between spasms. Clinical signs in experimentally infected red foxes were loss of appetite, diarrhea, and noisy labored breathing.In general, the gross and histopathologic lesions of tularemia in mammals resemble those of bubonic plague, or paratuberculosis, in rodents. Typical gross lesions are white foci or spots scattered throughout the liver (see illustration), spleen and lymph nodes, varying in size from pinpoint to large irregular conglomerate foci several millimeters in diameter. The spleen and liver may be dark bluish-red and enlarged.Lesions in naturally infected muskrats and beaver may include excessive clear dark fluid in the peritoneal and thoracic cavities; petechiae or minute hemorrhages in the subcutaneous fat; congestion in the lungs, liver and spleen; and focal necrosis in the spleen, liver, kidneys and mesenteric lymph nodes.