I've got a 5" GP100 in .357...not a common one, but balances perfectly.
I'd sight in for where you will most likely shoot.
The majority of my revolvers are sighted in for 25yds. Anything closer you don't have to compensate much, but gives a good baseline on those bunnies and grouse that you usually run across around 20-30yds away.
And you have your sight adjustments backwards.
Move the rear right, the bullet moves right.
Raise the rear sight, the bullet moves up.
I also agree with reloading.
Work up a load and load a ton of 'em the same.
I can load 158gr JHPs for a smidge under $9 a box.
My 160gr gas checked lead plinkers run a shade under $6.
Whats the going rate on .357 magnum now, $25 a box? Yikes!