A friend of our family who was a big game guide in Wyoming had this to say about cartridges. He said two of the most successful cartridges his hunters used was the 30-06 and the 300win. He said clients lost more game than any other cartridge combined using the 7mm rem mag. This hurts me to say it, but he was NOT a fan of the .270win either. What was his choice of cartridge...the .338 win mag. He loved his .338. That all said, my opinion is a good shot from any of the mentioned cartridges is a dead animal. Not looking for a fight here, just wanted to add that a very successful guide chose the .338win mag, and figured I'd tell his story.