I would suggest getting a Stoney Creek (now made by Hornady) OAL guage and one of the modified cases for 22-250. I have all of the stuff and am more than happy to help out if needed. Many 22 cals are pretty sensitive to how much jump to the lands you have, and some have a real sweet spot where accuracy really improves.
I would suggest picking a couple of bullets that you like. Try some minimum type loads loaded to published OAL with Varget, RL15 and H380. Figure out which bullet and powder your gun seems to prefer and then work up some loads. I typically work up powder charges until the bullet is going through the chrono at the speed I'm looking for and is accurate. Then I'll stick with that powder charge and start adjusting OAL until I find the sweet spot. At that point I will chrono again and adjust the charge as needed. When working up OAL make sure to load some dummy rounds at each longer length to make sure it will cycle through your action okay. As a general rule you want to make sure to have an amount equal to 80% of the bullet diameter seated in the case, or in the case of a .224 bullet about .18" of bullet base seated in the case. That is for adequate case neck tension, and more is usually better.
If you are really concerned with accuracy you may want to consider fire forming some cases to your rifle and then mostly neck sizing when reloading. I take it a bit further and typically case neck turn and check loaded rounds for runout, but it's pretty easy to go overboard. On the other hand, if you're using this gun for taking long range pokes at game every little bit of advantage helps.
If you want to do it quicker, down and dirty, it's hard to go wrong with H380 for most bullets in the 55gr range out of a 22-250.