Whether or not it can be done depends on the rifle, but the biggies are:
1) cannot use 209 primers. So ya gotta have a nipple that will work with #11s or caps
2) Primer must be visible (open to the elements) by the rifle's design. This one is a little grey. Doesn't spell out 'how open' and I think you can add 'stuff' to protect your primer from the elements as long as its not a part of the rifle. Like a strip of packing tape!
Then, of course, the bore diameter has to be min legal for the game you are hunting. So 40cal (I think) for deer and 45cal for anything bigger