Only one way to really know, go out and try.
I've shot groups at 200 yards that were the same size as my 100 yards groups. I've shot "groups" at 200 that left me scratching my head as well.
Now that my rifle/loads have proven themselves at 100 (averaging sub .4" with a 6x scope) I've changed my shooting. The last few times I shot in the mountains I wasn't going for groups anymore, just pick out rocks at different ranges and shoot them. If I can hit the rocks, I can hit the vitals. Have gone to 589 so far.