For the past dozen years my 30-06 hunting bullets have been Hornady 165 grain Interbonds and Swift A-frame in 180 grains. The 180 Swifts print one inch higher than the 165 Hornadies at 100 yards, vertically aligned. I can and do shoot those two bullets on a hunt with no need to adjust the scope. Have no idea if that would be true in another rifle.
The 180 Swift A-frame has the most consistent terminal performance on game of any bullet I've hunted with. Large wound channel and deep penetration in a straight line every time, for nearly 20 years. Have shot moose, caribou, mule deer, elk, blacktail deer and black bears with it at ranges from 20 feet to 250 yards. Consistent. It is over kill for coastal blacktails but it works!
I added the Hornady 165 Interbond because I have always liked 165 in 30-06 and have used it primarily for deer and one caribou.
There are many other good bullets out there that I have not shot. The Swift and Interbond work extremely well for me. I am working up a load for 165 Hornady GMX and if it performs well, will likely shoot everything with that.
Re Sierras: I shot 165 boattail Sierras at everything for 20 years in the 70's and 80's. They were the most accurate bullet I've worked with but fairly often they shed their jacket and stopped penetrating at that point. I'm sure that they are made to hold together better now but I moved on, first to Nosler Partitions, then to Swift, and added the Interbond later.