I love my Rino 530HCx... Generally I turn it on at the truck, let it get a decent signal, then stick it in the top pocket of my pack, or coat pocket, and let it track the whole time. If I'm not using the radio, I turn the radio off to save battery juice. If you leave it on the main menu screen, you'll save juice too (as opposed to leaving it on the map screen, where it constantly has to re-draw the map).
I set waypoints every time I find a decent game trail, fresh rub, big buck, etc. If I'm out scouting in the winter and there's snow on the ground, I'll set a waypoint every time there's decent tracks entering or leaving the road. This clues you in on frequently used trails that might not be obvious from the road. Then when I'm bored every once in a while, I'll download all the data from the GPS to the computer, and look at all the tracks and waypoints in both National Geographic TOPO! and Google Earth.
Yup a quality compass is always in the pack. Never *depend* on the GPS, but it hasn't let me down yet.