It will definitely work....... if you are committed to it. Jumping in a stand for an hour or two probably won't be that productive unless you are on a major food source at the perfect time of day. It will take skill and hard work.
The skill of stand hunting is scouting and picking the right location.
The work is all in the number of hours on stand your brain and body can tolerate. The people who say stand hunting isn't physically demanding are the people who have never sat in one for 6-8 hours straight. Your brain will be the first to tire. Your body can take WAY more abuse than your brain.
The little dude on your shoulder will be in your ear within a couple of hours. If your new to stand hunting he will start in on you within an hour. He says stuff like, "this location sucks" "what the hell are you doing up in a tree?" "I wonder what's up the trail another 200 yards" "your girlfriend thinks you're an sissy" It's hard not to listen to him after a while but he's usually wrong.
I have hunted from a tree stand for 15 years now. Two years ago I let that little dude convince me to get out of my stand one nasty rainy morning. It was about 11:00 am and I had been in the stand since 6:15. I stood up to get down and noticed some movement that I thought was a coyote. I grabbed my bow and made a few squeeks with my mouth to see if he would come in range. All of a sudden I'm staring down a cougar at 15 yards. I was already clipped on expecting to shoot a dog. I got a window to shoot and I whacked that sucker. An otherwise miserable day turned out to be one of the best hunting experiences of my life.