I shoot both these cals. BY FAR worst is a 95gn Nosler BT running around the 3200fps mark. Shoot em in the head and turn em into clowns with both eyeballs hangin out and a softball sized exit.
I since have got a custom turret for my load so now im shooting 95gn Berger VLDs at 3136fps and if you hit bone ur gonna get a pretty good sized exit. I hit one facing me last winter and hit it right between the shoulders and it exited between the back shoulder blades and you could have set a football in the hole.
22-250 I shot 50gn Nosler BTs and had a few nasty holes (max load est close to 4,000fps) If I were to hit bone on entrance it would blow up on entrance. Vmax's are terrible for blowing up on entrance. I also shot 52gn Seirras, shot a dog at maybe 10 yards with no exit. Last day I shot that load. (shot a dog about an hr later at about 220 and heart shot it and it ran about 60 yards with a golf ball sized exit. Now my load for the 250 is 52gn Bergers behind a 36.6gns of Varget.