Depends.
How old is the string?
Factory or after market string?
Do you shoot with a D-Loop?
What type of cam does your bow have?
It is not uncommon for new strings to have a rotation and then settle in after a few hundred shots. So that could be a concern.
Most older strings should have settled in. So rotation change is seldom an issue. D-Loops add a small amount of insurance on those older strings to help insure there are no surprises. But if you have an 8125 string all bets are off

Short single cam bows and original style binary cams often have a rotating peep. Luckily they repeat very consistent.
My favorite blind bow has a 90 degree peep twist. Same string for five years and never a single issue of change. I had thought about making a new string. Even thought about changing the cable guard and slider. But the bow is a real killer! It's something like 28/1 kill to miss ratio and the miss was a range mistake. So I just leave the darn thing alone until time to kill again! Just shot it three arrows
(6 yards, 50 yards and 80 yards) to make sure I'm good for turkey on Wednesday. Shoots just as good as it did on the first antelope five years ago

It never sees bad weather, never much UV light, and I never target practice with it other than to check zero before a hunt. Should have another year or two before I need to think about changing.
