Every barrel has it's sweet spot, two rifles of the same make and model will shoot different with the same load. Pick a bullet that is appropriate for the hunting you'll be doing. Then out of your loading manual pick a powder that will work for you, if your going to be doing a lot of paper punching and varmint hunting and going to be using a powder measure for volume loading I'd look at a short cut or ball powder. If your going to be weighing all your loads then anything works. My 243 is used for LR pred hunting and I weigh every charge and have had excellent results with 4064. Start low and work up a load that works for your rifle.
I have one rule that I adhere to NEVER use a load off the internet unless you can back it up in a loading manual.
AWS
