The .375 is going to be more versatile in Africa as well as Alaska. Unless you have the money to get an elephant, rino or hippo added to your safari the 375 is going to be the round to have. And, if you do have those funds why not take a full fledged traditional elephant rifle rather than the Alaskan. I guess that means my answer would be to keep the .375. It will do everything up north the .416 will and more.
Athough I did go sage rat hunting with my Ruger #1 in .458 Win and had a blast! All the guys in camp thought I had brought a bull barreled varmit gun. They about crapped their pants when I took that first shot

After a half dozen rats it lost it's humor pretty fast.
