I grazed the hair off a big cinnamons back last year because I held high shoulder on it at 360 yards shooting uphill about 100 yards in elevation. Not a drop of blood anywhere just a couple hairs 
PathfinderJR learned this lesson 2 years ago (he was 12) when he whiffed over a whitetail doe's back twice at 250 yards by aiming center-mass. Finally on the 3rd shot he listened to me when I said "hold low". He thought I meant to hold an inch or two low, not at the bottom of her brisket. Third shot pinwheeled her. Luckily, the angle was so steep that she had no idea what was shooting at her and she just kept looking around.
He learned his lesson though. 3 hours later he filled his late season buck tag on a 147" whitey that was 290 yards, steep uphill and facing straight towards us. One shot, bullet went into the center of his chest and out behind his ribs. He fired, got up and said "He's dead. I knew to hold low that time...."
