Absolutely! 12 ga slugs are deadly. I love hunting with mine. I've shot a bison with it and at least a dozen deer. If you have a rifled barrel and a scope you could kill a bear out to 150 yards or more. I have my Thompson Pro Hunter sighted in at 125 yards. It's deadly accurate with the 28 inch rifled barrel. I like the Winchester Supreme ammo with 385 grain Nosler Partition slugs. It took a while to find what my gun liked to shoot so I would recommend spending a lot of time at the range figuring out what your gun shoots the best.