I have the bug get a new big bore revolver and I can't decide on the caliber. I've played with pretty much every revolver round from 357 mag up to the big 45s (454, 460, 45-70). I even had a 500 S&W for a while, but the revolver was so big and heavy that I never carried it. I think I have it narrowed down to either a 475 Linebaugh or one of the mid sized 50s (500 JRH, 500 Linebaugh, 510 Reeder, 50 WE). The 50s are all in the same league, and the 475 is right there with them with arguably better penetration. Not that any of them wouldn't give a complete pass through on pretty much anything.

The revolver itself with be either a BFR from the Magnum Research precision center, Freedom Arms, or a Gary Reeder conversion. The Freedom Arms and Reeder revolvers both take about 10-12 months to get and a BFR can be had in about 6 weeks. All of them are high quality guns. I've owned and shot a number of BFRs, and I've shot both Freedom Arms and Reeder revolvers. The BFR is the least expensive (about $1500) and the others are right about the same price ($2000). The whole idea is to have a 5.5-6" gun of reasonable weight to pack around.
So if any of you have any experience with with any of these calibers or guns, speak up!
Andrew