I'm a real fan of bullet weight (308 in 165gr.) when the hit is a little off and you end up busting your way through a leg bone, or an injured bear that needs another round when all you have is his south end when he's heading north. It changes the game a bit for me when you're shooting something that can eat you. Having said that, just about any round from .25 on up kills under ideal conditions; but hunting is seldom ideal.