I did some research on reloading . 45LC. What I found was that most .45 LC revolvers sights are designed for the ballistics of 250 gr bullet. Generally speaking if you load other than 250’s your POA will be significantly off POI. Without refreshing my memory I think it was something like 6” in 25 yds? I found this out after receiving a bunch of 220’s for a birthday gift. I haven’t compared 250’s vs. my 220’s side by side, but my 220’ s were definitely off POA. This was last year and I’ve only had the gun out that one time. You might want to double check this before investing in a bunch of bullets.