Just choose your bullet wisely and you'll have no problem taking any animal up to around 1000 pounds. Beyond that, and I'd still use it but only broadside, no quarting-to shots and only slight angle quartering away.
As far as questions about blood trails and such, the 270 Winchester does as much internal damage as I've ever seen. It seems like more so than the bigger 30 calibers and 33 calibers. With today's bullets, its a great combination of lighter recoil, flat trajectory and good on-game performance.
AND....You can find ammo anywhere just in case for super-reasonable prices compared to the other stuff out there today.